pg_0062
The Patent Office Journal, 27.05.2005
15886
The following patent applications have been published under section 11A of the Patents
(Amendment) Act, 2002.
(21). Application No. 01307/DELNP/2003, A (22) Date Of Filing Application: 18/08/2003
(54) Title Of The Invention: "NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE
COMPOUNDS AND THEIR USE TO TREAT DISEASES"
(51) International Classification
7
: C07D (71) Name Of The Applicants:
BRISTOL-MYERS SQUIBB COMPANY
Address Of The Applicants:
of Larenceville-Princeton Road, P.O. Box 4000,
Princeton, New Jersey 08543-4000, USA
(72) Name Of The Inventor:
i) KIMBALL, Spencer, David
ii) LOMBARDO, Louis, J.
iii) RAWLINS, David, B
iv) XIAO, Hai-Yun
v) SCHMIDT, Robert, Joseph
vi) WILLIAMS, David, Kent
(57). Abstract:
The present invention provides compounds of formula (I) and pharmaceutically
acceptable salts thereof;
The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer
agents. The formula I compounds are also useful for the treatment of other diseases which can be
treated by inducing mitotic arrest.
NC
R
1
R
2
R
3
Z
N
H
N
R
4
Formula; I
