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The Patent Office Journal 23/09/2005
22157
(12)
PATENT APPLICATION PUBLICATION
(19) INDIA
(21) Application No.: IN/PCT/2001/00032
A
(22) Date of filing of Application: 09/01/2001 (43) Publication Date:23/09/2005
(54) Title of the invention:
: QUINOLINE DERIVATIVES
(51) International classification : C07D 215/56,
215/36, 215/22,
A61K 31/47
(31) Priority Document No
: 9802550-5
(32) Priority Date
: 15/07/1998
(33) Name of priority country : SE
(86) International Application
No and Filing Date:
: PCT/SE99/0127
1 & 14/07/1999
(87)
International Publication No
: WO
00/03992 A1
(61) Patent of addition to
Application No
:
NA
Filed on
: NA
(62)
Divisional to Application No
: NA
Filed on
: NA
(71) Name of Applicant:
ACTIVE BIOTECH AB.,
Address of the Applicant:
P.O.BOX 724, S-220 07 LUND
SWEDEN.
(72) Name of the Inventor:
BJORK, ANDERS
JONSSON, STIG
FEX, TOMAS
HEDLUND, GUNNAR
Filed U/S 5(2) before The
Patents (Amendment)
Ordinance, 2004: YES
(57) Abstract:
The invention is related to compounds of general formula (I) wherein R is Me, Et, n-Pr, iso-Pr, n-Bu, iso-Bu,
sec.-Bu or allyl; R' is hydrogen, Me, MeO, fluoro, chloro, bromo, CF
3
, or OCH
x
F
y
; R'' is hydrogen or fluoro,
with the proviso that R'' is fluoro when R' is fluoro; and further when R' and R'' are both hydrogen, R is not Me;
R
4
is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R
5
is selected
from MeS, EtS, n-PrS, iso-PrS, MeSO, EtSO, MeSO
2
and EtSO
2
; wherein x=0-2, y=1-3 with the proviso that
x+y=3; and Me is methyl, Et is ethyl, Pr is propyl and Bu is butyl; and any tautomer, optical isomer and
racemate thereof. The invention also relates to pharmaceutical compositions containing a compound of general
formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation
of the compounds of formula (I), as well as methods for the treatment of mammals suffering from diseases
resulting from autoimmunity and pathological inflammation by administering of a compound having formula
(I) to said mammal
(FIG.)nil
