Biotechnology

Gene Mapping

Gene mapping is the technique used primarily in the field of genetic Engineering .This is primarily used to locate the specific chromosome which responsible for the cause of genetic diseases.

The total number of patents available for this title is listed below. This patent is very important which helps the human race by reducing the probability of genetic diseases or hereditary disease.

Patent No: 6,909,971 titled ‘Method for gene mapping from chromosome and phenotype data’ with the abstract : The present invention relates to a method for gene mapping from chromosome and phenotype data, which utilizes linkage disequilibrium between genetic markers m.sub.i, which are polymorphic nucleic acid or protein sequences or strings of single-nucleotide polymorphisms deriving from a chromosomal region. All marker patterns P that satisfy a certain pattern evaluation function e(P) are searched from the data, each marker m.sub.i of the data is scored by a marker score and the location of the gene is predicted as a function of the scores s(m.sub.i) of all the markers m.sub.i in the data.

Patent No: 6,489,109 titled ‘Transcription-based gene mapping’ with the abstract: The present invention relates to methods for mapping expressed nucleic acid sequences to their chromosomal location. The invention also related to methods for mapping gene response patterns in hybrid cells containing expressed genes located on exogenous chromosomal segments.

Patent No: 5,470,709 titled ‘Gene mapping by hybridization to free chromatin’ with the abstract : A method is provided for detecting, ordering and mapping genes or DNA sequences in the genome of eukaryotic cells. The method comprises the steps of releasing free chromatin from the nuclei of the cells and contacting the released free chromatin with at least one detectable probe capable of hybridizing to the genes or DNA sequences to be detected, thereby rendering the genes or DNA sequences detectable.

Patent No: 5,102,785 titled ‘Method of gene mapping’ with the abstract : The method described characterizes each DNA segment to be mapped by cleaving it to produce DNA fragments which are then end labeled with a reporter(s) specific to the end nucleotides of each fragment. The labeled fragments are again cleaved to produce short fragments which are separated according to size. The short fragments are analyzed as to report identify and size which is indicative of the character of each fragment. By derivatizing the cleaved ends of the primary cleaved fragments, the labeling may be delayed until the second cleavage. Prior to the labeling the derivatized fragments, all underivatized fragments are removed, the derivatized fragments being immobilized.

Patent No: 5,851,762 titled ‘Genomic mapping method by direct haplotyping using intron sequence analysis’ with the abstract : The present invention is an improved genomic mapping method which is able to generate highly informative polymorphic sites throughout the genome. In addition to being highly polymorphic, the sites can be used to generate patterns that identify allelic and sub-allelic haplotypes associated with the region. Patent No: 7,129,324 titled ‘Secreted and transmembrane polypeptides and nucleic acids encoding the same’ with the abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention