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Cell adhesion molecules refer to the bio-molecules that help the cells to get adhered to the substrate for better results. Some of the patented techniques are given below.
Patent no: 6,413,538 titled ‘Bioactive glass or ceramic substrates having bound cell adhesion molecules’ with the abstract: Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The bioactive glass and ceramic materials are treated such that when used in contact with anchorage-dependent cells, there is enhanced cell attachment and cell function to provide expeditious tissue growth in vitro or in vivo. Treatment involves immersing the glass or ceramic material in an aqueous solution containing ions in a concentration typical of interstitial fluid followed by immersion in an aqueous solution containing at least one cell adhesion molecule. Immersion may also be in an additional aqueous solution containing an additional cell adhesion molecule before or after immersing in the solution containing ions. The glass material is preferably formed from SiO.sub.2, CaO, Na.sub.2 O and P.sub.2 O.sub.5. The glass material is preferably prepared by melting constituents, cooling and pulverizing the resultant glass to obtain a powder, and then forming and hot pressing the powder. The glass may be formed to produce templates, a swell as to produce granules that may be formed into a paste. An implant may be formed by coating an implant material with the treated bioactive glass or ceramic material.
Patent no: 5,719,268 titled ‘Endothelial cell adhesion molecules’ with the abstract: Methods and compositions are provided for the modulation of monocyte binding to endothelial cells, particularly during inflammatory episodes. Compositions are provided which bind to one or both of the monocyte surface membrane protein or the endothelial surface membrane protein which are complementary or result in the adhesion of the monocyte to the endothelial cell. The subject compositions can be used in diagnosis or therapy.
Patent no: 5,625,040 titled ‘Phosphacan: a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell adhesion molecules’ with the abstract : A phosphacan proteoglycan molecule, or a functional derivatives thereof, binds to brain cells and to a number of cell adhesion molecules including Ng-CAM and N-CAM. Such proteoglycan molecules or functional derivatives, as well as nucleic acids coding therefore are useful in treating a subject having a disorder associated with conditions where it is desirable to promote nerve regeneration. The compositions and methods of the present invention are also useful for diagnosing and monitoring human tumors such as gliomas and astrocytomas.
Patent no: 5,521,067 titled ‘Bone marrow cell adhesion molecules and process for detecting adherence between cell adhesion molecules and cells generally’ with the abstract : The present invention relates to proteins associated with human bone marrow cell membranes for adhering hematopoietic cells to human bone marrow cell membranes. These proteins are soluble in lithium dodecyl sulfate but insoluble in 2% nonaethylene glycol octylphenol ether (e.g., 2% Triton.RTM. X-100) solution. These proteins and antibodies raised against them are useful in the treatment and diagnosis of blood disorders. The DNA molecules encoding these proteins have use in gene therapy regimes. Also disclosed is a method for detecting binding between cell adhesion membrane proteins and cells having a potential to be bound to such proteins.
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Cell Adhesion Molecules
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