Functional Genomics refers to the field of molecular biology which makes use of the vast data produced by genomics projects to explain the gene functions and interactions.
Some of these methods that are patented in USPTO are given below. There are a total of 13 methods that are patented.
Patent no: 6,777,185 titled ‘Functional genomics using zinc finger proteins’ with the abstract: The present invention provides methods of regulating gene expression using recombinant zinc finger proteins, for functional genomics and target validation applications.
Patent no: 7,029,848 titled ‘High throughput screening of gene function using libraries for functional genomics applications’ with the abstract: Novel means and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids, or GSEs. The sample nucleic acids are expressed in a host by a vehicle to alter at least one phenotype of the host. The altered phenotype(s) is/are identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).
Patent no: 6,413,776 titled ‘High throughput screening of gene function using adenoviral libraries for functional genomics applications’ with the abstract: Novel adenovirus vectors and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids or GSEs. The sample nucleic acids are expressed in a host by recombinant adenovirus vectors to alter at least one phenotype of the host. The altered phenotype(s) is identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).
Patent no: 6,333,155 titled ‘Exploiting genomics in the search for new drugs’ with the abstract: The cellular effects of potentially therapeutic compounds are characterized in mammalian cells and yeast. In the latter case the effects can be characterized on a genome-wide scale by monitoring changes in messenger RNA levels in treated cells with high-density oligonucleotide probe arrays.
Patent no: 6,340,567 titled ‘Genomics via optical mapping with ordered restriction maps’ with the abstract: A method of producing high-resolution, high-accuracy ordered restriction maps based on data created from the images of populations of individual DNA molecules (clones) digested by restriction enzymes. Detailed modeling and a statistical algorithm, along with an interactive algorithm based on dynamic programming and a heuristic method employing branch-and-bound procedures, are used to find the most likely true restriction map, based on experimental data.
Patent no: 7,008,767 titled ‘Microorganism genomics, compositions and methods related thereto’ with the abstract: The present invention provides methods and composition for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.
Patent no: 6,783,930 titled ‘Development of novel anti-microbial agents based on bacteriophage genomics’ with the abstract: A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.
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