Process of Bio-Reduction refers to the important metabolic process which controls the fate and transport of heavy metals and radionuclides. Some of the process patented in USPTO are given below.
Patent no: 5,948,260 titled ‘Process for bioreduction of propelleant wastewater’ with the abstract: A process for treatment and disposal of wastewater having dissolved perchlorate salts is described and includes the steps of adding to the wastewater in a hydrogen gaslift recycle reactor a mixed bacterial culture containing the specific bacterium HAP1 for reducing the perchlorate ion to chloride in the wastewater; maintaining proper nutrient and environmental conditions for HAP1 to optimally reduce perchlorate in the wastewater; and discharging effluent wastewater from the gaslift reactor to an aerobic reactor and maintaining proper nutrient and environmental conditions for the optimal conversion of soluble organics to carbon dioxide and sludge.
Patent no: 5,900,368 titled ‘Process for bioreduction of bisaryl ketone to bisaryl alcohol’ with the abstract: The present invention is directed to an improved process for making PDE IV inhibitors. In specific, this application describes a process for making and purifying a chiral bisaryl alcohol, an intermediate compound necessary for the preparation of PDE IV inhibitors such as CDP 840, by asymmetric bioreduction of a pro-chiral ketone. Furthermore, the bioprocess provides for production of each enantiomer of a bisaryl alcohol at elevated optical purity. This invention takes advantage of a microorganism's ability to reduce a pro-chiral bisaryl ketone to the chiral bisaryl alcohol. The alcohol is readily isolated from the media by solvent extraction, crystallography, or other purification method known to the skilled artisan. The chiral alcohol can then be converted to a PDE IV inhibitor, such as CDP 840, by methods well known in the art.
Patent no: 6,916,136 titled ‘Aerobic bioreduction of municipal solid waste landfill mass’ with the abstract: A process for converting municipal solid waste landfills to aerobic conditions that will allow for a highly accelerated and enhanced bioreduction of landfill mass, followed by the optional excavation of the landfill cell materials subsequent to the bioreduction process, separation of excavated materials using trommels, screens, and other means as necessary, production of useable compost materials, and reclamation of recyclable plastics, metal, and glass.
Patent no: 6,764,842 titled ‘Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates’ with the abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin .alpha.v.beta.3 receptor antagonists. ##STR1##
Patent no: 5,900,368 titled ‘Process for bioreduction of bisaryl ketone to bisaryl alcohol’ with the abstract: The present invention is directed to an improved process for making PDE IV inhibitors. In specific, this application describes a process for making and purifying a chiral bisaryl alcohol, an intermediate compound necessary for the preparation of PDE IV inhibitors such as CDP 840, by asymmetric bioreduction of a pro-chiral ketone. Furthermore, the bioprocess provides for production of each enantiomer of a bisaryl alcohol at elevated optical purity. This invention takes advantage of a microorganism's ability to reduce a pro-chiral bisaryl ketone to the chiral bisaryl alcohol. The alcohol is readily isolated from the media by solvent extraction, crystallography, or other purification method known to the skilled artisan. The chiral alcohol can then be converted to a PDE IV inhibitor, such as CDP 840, by methods well known in the art.
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