Synthetic peptide vaccine refers to a vaccine consisting mainly of synthetic peptides, carbohydrates, or antigens. Some of the techniques patented in USPTO are given below.
This helps the humans to protect themselves and animals from various diseases.
Patent no : 6,827,936 titled ‘Synthetic peptide vaccines for dental caries’ with the abstract Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, and equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.
Patent no: 6,107,021 titled ‘Synthetic peptide vaccines for foot-and-mouth disease’ with the abstract : The present invention relates to the use of a peptide composition as an immunogen, with each peptide contained therein comprising a target antigenic site derived from the VP1 capsid protein of Foot-and-Mouth Disease Virus (FMDV). The antigenic site is covalently linked to a helper T cell epitope and, preferably, to other immunostimulatory sequences, preferably by conventional peptide bond(s) through direct synthesis, for the prevention of FMDV infection and eradication of Foot-and-Mouth Disease (FMD). More particularly, the present invention relates to the use of such peptide composition as an immunogen to elicit the production in animals including swine, cattle, sheep, goats and susceptible wild species, of high titer polyclonal antibodies that can effectively neutralize, in vitro, multiple strains or serotypes of FMDV, and to the use of such composition as a vaccine to prevent, and/or reduce the incidence of, FMDV infection regardless of serotype, and thus affect the eradication of FMDV. The present invention also relates to the peptides used in the compositions, and to immunoassays and/or diagnostic kits containing one or more of these peptides, and methods of diagnosing FMDV in mammals using such materials.
Patent no : 5,733,550 titled ‘Method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells with .beta.-microglobulin’ with the abstract :The present invention provides a method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells to thereby sensitize the target cells for class I MHC-restricted cytotoxic T cell response. The method involves obtaining the peptides of interest and presenting the peptides to the appropriate antigen presenting cells in the presence of an elevated level of free .beta..sub.2 -microglobulin. The method of the present invention can also be used to prime naive populations of T lymphocytes for antigen-specific class I MHC-restricted cytotoxic T cell response with exogenous peptide and is useful in both in vitro and in vivo applications. A new use for purified .beta..sub.2 -microglobulin as an adjuvant for synthetic peptide vaccines is also provided.
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