Tumor vaccine refers to the vaccine which inhibits the growth of the malignant and non malignant cells. Some of the patented methods involved in the preparation of vaccine are given below.
Patent no: 7,084,249 titled ‘Tumor associated antigen peptides and use of same as anti-tumor vaccines’ with the abstract: The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules.
Patent no: 6,051,428 titled ‘Rapid production of autologous tumor vaccines with the abstract An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES; intercellular adhesion molecules, for example ICAM-1 and costimulatory factors such as B7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins.
Patent no : 5,582,831 titled ‘Anti-tumor vaccines’ with the abstract An immunogen derived from modified tumor cells and capable of inducing an anti-tumor immune response is prepared in accordance with the invention by exposing tumor cells to a crosslinking agent, which is a 2',3'-nucleoside or nucleotide dialdehyde at a concentration and for a time sufficient to cause crosslinking of proteins in the cells' plasma membranes. Improved immunogenicity may be obtained if the cells are also exposed to hydrostatic pressure at a level and for a time sufficient to cause displacement of the proteins in the cells+ plasma membranes. Exposure of the tumor cells to the crosslinking agent and to hydrostatic pressure at the same time is a preferable method of producing the immunogen. The immunogen is suitable for use as an anti-tumor vaccine for inducing an anti-tumor immune response in cancer patients.
Patent no: 4,931,275 titled ‘Anti-tumor vaccines and their preparation’ with the abstract: here are provided anti-tumor vaccines which contain as active ingredient tumor cells which have been pressure treated so as to augment their antigenic properties, tumor cells treated with cholesteryl hemisuccinate (CHS) and subsequently pressure treated, or plasma membranes from either of, or membrane proteins shed from either of these cells, or a combination of any of these. According to another embodiment, tumor cells are treated with cholesteryl hemisuccinate or by the application and release of pressure, and subsequently with a cross-linking agent. Such cells, plasma membranes obtained from these and proteins shed from the surface of these are effective active ingredients in anti-tumor vaccines.
Patent no: 5,273,745 titled ‘Virus-modified tumor vaccines for immunotherapy of tumor metastases’ with the abstract: The invention discloses a virus-modified tumour-specific vaccine consisting of corresponding separated tumour cells inactivated by irradiation and incubated with NDV (Newcastle Disease Virus) under sterile conditions in serum-free medium. The vaccine may optionally be irradiate
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